Welcome to the PGC Video Training Textbook!

Hello! I’m Cathryn Lewis from King’s College London, and I’m the Education and Training lead for the Psychiatric Genomics Consortium. I’m very pleased to welcome you to the PGC’s Video Training Textbook.

The aim of the textbook is to provide comprehensive training materials in psychiatric genetics. We start with an introduction to mental health disorders, give a background to genetics and the technologies used to generate genetic data, and then we step through the methods that are used to analyze that genetic data, from quality control, to genome-wide association studies, to polygenic scores, and pathway analysis.

These videos have been collated from online resources, including those produced for the Psychiatric Genomics Consortium, and others from external groups. They range in length from a few minutes, to an hour, and cover both teaching lectures, and methods tutorials. Some videos are marked as “Basic”, “Intermediate”, or “Advanced”, so you can plan your learning program accordingly.

You can use the textbook in any way you choose, working systematically through each section, or picking specific topics that you want training in. If you identify areas that we don’t cover, or that you want to suggest additional videos for, please let us know! The textbook is a flexible resource that we hope to update regularly.

Finally, a huge thank you to the team, who have given their time, their energy, and their enthusiasm to create the textbook. This is an international team from the US, Europe, and New Zealand, and it’s been a great pleasure to work together.

We hope that this Psychiatric Genomics Consortium Video Training Textbook fills a need in building capacity in the psychiatric genetics community, and so, enables us to train a new generation of researchers worldwide. With the rapid expansion of available genetic data, the need for skilled analysts has never been greater! And that is an essential step, if we are to realize the potential of using genetics to improve the prevention, diagnosis, and treatment of mental health disorders. And I hope the Video Training Textbook helps you achieve that aim.

The Video Textbook Team

In alphabetical order:

**Anna Docherty PhD**: Associate Professor, Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA

**Howard J. Edenberg PhD**: Distinguished Professor, Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA

**Lachlan Gilchrist MSc**: PhD Student, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK

**Laura Huckins PhD**: Associate Professor, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

**Jessica Johnson MPH**: Data Scientist, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

**Hannah Kennedy PhD**: PostDoctoral Researcher, Department of Psychological Medicine, University of Otago, Christchurch, New Zealand

**Ada P. Kępińska PhD**: PostDoctoral Researcher, Departments of Psychiatry and Genetics and Genomic Sciences, The Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA

**Cathryn Lewis PhD**: Professor, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK

**Chris Lo**: PhD Student, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK

**Grace D. Lutter**: Social/Clinical Research Specialist, Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

**Elizabeth Mikita MPH**: Research Data Analyst, Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

**Caroline Nievergelt PhD**: Professor, Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

**Carina Seah MS**: MD PhD Candidate, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY

**Kayla Townsley Bs**: PhD Candidate, Departments of Neuroscience and Genetics and Genomic Sciences, The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

**Tim Van Der Es Msc**: PhD Student, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK

**Jiayi Xu PhD**: Associate Research Scientist, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

Kelleigh Hogan: Statistical and Research Data Analyst, Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

Michelle Kamp: PhD Student, Division of Human Genetics, Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa.

Adam Maihofer PhD: Assistant Project Scientist, Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

Oliver Pain PhD: Postdoctoral Research Associate, Social Genetic and Developmental Psychiatry Centre, King’s College London, London, UK.

Portuguese Translations

Translations of video transcripts are available in Portuguese thanks to the incredible work of the following individuals:

Marcos Santoro, PhD: Adjunct Professor, Departamento de Bioquímica, Universidade Federal de São Paulo, Brazil.

Lucas Toshio Ito: PhD student, Departamento de Bioquímica, Universidade Federal de São Paulo, Brazil.

Júlia Arendt: PhD student, Departamento de Bioquímica, Universidade Federal de São Paulo, Brazil.

Rafaella Ormond: PhD student, Departamento de Bioquímica, Universidade Federal de São Paulo, Brazil.

About the Psychiatric Genomics Consortium

The Psychiatric Genomics Consortium

Title: PGC: Future Perspectives

Presenter(s): Patrick Sullivan, MD, FRANZCP (Department of Genetics, Department of Psychiatry, University of North Carolina at Chapel Hill)

Length: 33:33

Link to video transcript here.

PGC Website