Welcome to the PGC Video Textbook!

Here, we’ve pulled videos from our PGC experts to give a comprehensive overview of Psychiatric Genetics: From its history to current state of research, and resources for conducting analyses in Psychiatric genetics.

Each video is embedded into the textbook webpage, and a link to the video transcript has been provided below the video.


Table of Contents:

Welcome and Introduction

Chapter 1: Introduction

1.1: What are Psychiatric Disorders?

1.2: Epidemiology

1.3: History

1.4: Psychiatric Genomics: State-of-the-Science

Chapter 2: The Genome

2.1: Organisation of the Genome

2.2: Types of Genetic Variation

2.3: Evolutionary Signatures

2.4: Linkage Disequilibrium

2.5: Genome References

Chapter 3: Technologies

3.1: SNP Array Genotyping

3.2: Next Generation Sequencing

Chapter 4: Study Designs

4.1: Epidemiological Study Design

4.2: Confounding, Chance, and Bias

4.3: Genetic Study Designs

Chapter 5: GWAS Analysis

5.1: Genotyping Quality Control

5.2: Imputation

5.3: Association Testing

5.4: Meta-Analysis

Chapter 6: Polygenic Scores

6.1: Polygenic Risk Scores

Chapter 7: Ancestry-Specific Analysis

7.1: Cross-Ancestry Analysis

7.2: Ancestry-Specific PRS

7.3: Local Ancestry and Admixed Populations

Chapter 8: Post-GWAS Bioinformatics

8.1: SNP Heritability

8.2: Genetic Correlations and Partitioned LDSC

8.3: Gene-Association Analysis

8.4: Gene-Set Analysis

8.5: Fine-Mapping

8.6: Quantitative Trait Loci (QTLs)

8.7: TWAS

8.8: pheWAS

Chapter 9: Advanced Topics

9.1: Copy Number Variation

9.2: Mendelian Randomization

9.3: Genomic Structural Equation Modeling

9.4: Interactions with Environmental Factors

9.5: Family-Based Analysis

9.6: Therapeutic Implications

Chapter 10: Other Considerations

10.1: A Career in Psychiatric Genetics

10.2: Caution in Genetic Prediction

10.3: Small Effect Sizes

10.4: Language in Genetics Research

10.5: Equitable Collaboration for LMIC Researchers

10.6: GDPR for Dummies

Software tutorials

CNVs

Conditional Analysis

Cross-Disorder Analysis

Datasets

Epigenome-Wide Association Studies

Gene Set Identification

Genome-Wide Association Studies

Genomic SEM

Mendelian Randomization

Multi-Trait Analysis of GWAS

Polygenic Risk Scores

SNP Heritability and Genetic Correlation

Glossary

Software Resources